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Patients already on a stable GLP-1 protocol who want metabolic support during their fat-loss phase tend to do well adding MOTS-C two or three times per week

Constipation is less dose-dependent and can persist, making it a more durable reason for discontinuation in patient reports. Sulfur burps reflect food sitting longer in a slowed stomach. Fatigue ranks second only to nausea in patient forums, although much of it tracks the calorie deficit rather than tirzepatide itself. Fried or fatty foods, coffee, meat, and alcohol can also become less appealing

Managing nephrotoxicity is possible

This may be easier when using the help of another person